Hesperidin and diosmin are closely related citrus flavanones, yet they behave very differently in a finished product. Understanding the difference helps formulators pick the right ingredient the first time.

Origin and chemistry

Hesperidin is extracted directly from citrus peel. Diosmin does not exist in nature in meaningful quantities — it is produced by converting hesperidin through microbial enzymatic dehydrogenation. That extra step is why pharmaceutical-grade diosmin commands a premium.

Practical selection tips

• Solubility: both are poorly water-soluble; micronized grades dramatically improve dispersion in liquids.
• Market position: hesperidin suits classic supplement and food-fortification applications, while diosmin dominates clinical leg-health formulations.
• Specifications: ask for HPLC assay, heavy metals and microbiology reports with every batch.

Our technical team routinely helps customers match grade and particle size to their application — contact us for samples.